This whitepaper introduces the initial set of O-RAN use cases and cloud native deployment support options. The first part of the whitepaper covers O-RAN use cases that are both leveraging the O-RAN architecture and demonstrating its unique benefits including utilization of AI/ML modules to empower network intelligence through open and standardized interfaces in a multi-vendor network. After the use cases, O-Cloud, the cloud computing platform comprising a collection of physical infrastructure nodes that can host the relevant O-RAN functions, the supporting software components, the appropriate management and orchestration functions are introduced, enabling flexible deployment options in virtualized telco clouds.